Pistons vs. Knicks Picks and Prediction – 4/21/2025

Detroit Pistons (0-1) vs. New York Knicks (1-0)
Time: 7:30 PM ET
Location: Madison Square Garden, New York, NY
TV: TNT / truTV / Max

Previous Game:

  • Knicks: Won Game 1, 123-112

  • Pistons: 19 turnovers in Game 1, struggled late in the 4th

Head-to-Head:

New York has now won 18 of the last 21 meetings against Detroit, including a dominant Game 1 where they turned an 8-point 4th quarter deficit into a double-digit win. The Knicks are 5-1 ATS in their last 6 at home, while Detroit continues to struggle both straight up and ATS.

Detroit Pistons Breakdown:

Detroit showed offensive flashes in Game 1, shooting 48% from the field and hitting 15-of-32 from three. Tobias Harris led with 25 points, Cade Cunningham added 21 points and 12 assists, and Malik Beasley had 20 off the bench. However, turnovers (19) and poor late-game execution killed any chance at a comeback. The possible absence of Isaiah Stewart (knee) only makes things tougher defensively inside.

Key Players:

  • Cade Cunningham: 21 PTS, 12 AST

  • Tobias Harris: 25 PTS, 6 REB

  • Malik Beasley: 20 PTS off the bench

New York Knicks Breakdown:

The Knicks put together a complete performance in Game 1 behind Jalen Brunson’s 34 points and 8 assists. They shot 53% as a team and won the physical battle late. OG Anunoby and Karl-Anthony Towns both added 23 points, while the bench, led by Cameron Payne, contributed effectively. Defensively, New York clamped down when it mattered most and should feel confident heading into Game 2.

Key Players:

  • Jalen Brunson: 34 PTS, 8 AST

  • OG Anunoby: 23 PTS

  • Karl-Anthony Towns: 23 PTS

Betting Trends:

Detroit Pistons:

  • 1-5 ATS in their last 6 games

  • 3-17 SU in their last 20 vs. New York

  • Failed to cover +6.5 in 4 of their last 5 road games

New York Knicks:

  • 8-3 ATS in their last 11 games

  • 5-1 ATS in their last 6 at home

  • Covered -6.5 in 7 of their last 10 home games

Exact Score Prediction:

New York Knicks 115 – Detroit Pistons 107

Our Best Bet:

New York Knicks -6.5 (-110)

The Knicks' ability to pull away in Game 1 — especially with a 21-0 fourth quarter run — shows they can dominate late when it counts. Detroit lacks the defensive depth and consistency to keep up over four quarters, especially if Stewart is out. New York has covered this number in 7 of their last 10 at home and is in much better form overall. The Pistons may hang early, but the Knicks should separate again late and cover the spread with ease.

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